AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics

Abstract The aggregation‐induced emission luminogens (AIEgens) with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes. In this review, we first presented numeral classic types based on light‐up AIEgens real‐time monitoring processes evaluation therapeutic outcomes delivered or Next, general strategies were discussed delicately structural design that can self‐assemble into bright carriers through covalent noncovalent interactions. Furthermore, given unprecedented enhancements in effects use multimodes therapy, endowed multi‐properties functionalities investigated constructions multimodality therapy. Especially, combinational uses AIE photosensitizers chemo drug small interference RNA (siRNA) as examples augmenting performance drug‐resistant treatment moderate immunotherapy by showing synergistic effects.